| 摘要 |
PURPOSE: Anticancer compounds isolated from leaves of Crinum latifolium, derivatives thereof and an anticancer composition containing the same are provided, thereby preventing and treating cancers effectively. CONSTITUTION: Anticancer compounds isolated from leaves of Crinum latifolium include 6,7-dimethoxy-4-(3-methyl-2-butenoyloxymethyl) coumarin of the formula I, and 5,6,3 -trihydroxy-7,8,4 -trimethoxyflavon of the formula II. Another anticancer compound represented by the formula III is provided, wherein R is C1-C3 alkyl. A process for preparing the compound of the formula III comprises the steps of: (i) condensing 3,4-dioxyphenol and ethyl 4-chloroacetate by a Pechman method in sulfuric acid to prepare 4-chloromethyl-6,7-dimethoxycoumarin; and (ii) reacting 4-chloromethyl-6,7-dimethoxycoumarin with organic acid in the presence of triethylamine.
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