发明名称 |
Phosphonsyrederivater med metallopeptidaseinhiberende aktivitet |
摘要 |
<p>Compounds of formula (I) wherein R is an alkyl, aryl or arylalkyl group wherein the aryl is phenyl naphthyl or heterocycle; R1 and R2, the same or different, are hydrogen atoms or alkyl groups; R3 is an aryl or arylalkyl group wherein the aryl is as above; R4 is a heterocycle optionally substituted with a heterocycle or phenyl, or it is a phenyl group substituted with a heterocycle (R4 is not imidazole or indole); X is a bond or -OCONH or -CONH- group, processes for their preparation and pharmaceutical compositions thereof, are described. The compounds of formula (I) are endowed with a dual ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular disease.</p> |
申请公布号 |
DK0868428(T3) |
申请公布日期 |
2003.07.21 |
申请号 |
DK19960938164T |
申请日期 |
1996.11.11 |
申请人 |
ZAMBON GROUP S.P.A. |
发明人 |
NORCINI, GABRIELE;BOTTA, DANIELA;SANTANGELO, FRANCESCO |
分类号 |
A61K38/00;A61K31/00;A61K38/05;A61P9/00;A61P9/04;A61P43/00;C07K5/06;C07K5/062;C07K5/065;(IPC1-7):C07K5/062 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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