| 发明名称 |
PROTEASE ACTIVATED RECEPTOR 2 VARIANTS. |
| 摘要 |
<p>A variant PAR-2 receptor polypeptide or a fragment thereof is provided which (i) has reduced sensitivity to trypsin as compared with wild type PAR-2; (ii) has increased sensitivity to trans-cinnamoyl-LIGRLO-NH2 as compared with wild type PAR-2; and (iii) is activated by TLIGRL-NH2, which polypeptide or fragment thereof comprises an extracellular loop 2 (ECL-2) having at least one amino acid difference from the corresponding ECL-2 amino acid sequence of the wild type polypeptide.</p> |
| 申请公布号 |
MXPA01010380(A) |
申请公布日期 |
2003.07.21 |
| 申请号 |
MX2001PA10380 |
申请日期 |
2000.04.17 |
| 申请人 |
UNIVERSITY OF SOUTHAMPTON |
发明人 |
WALLS, ANDREW, FINLAY |
| 分类号 |
G01N33/50;A61K45/00;A61P1/04;A61P9/12;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P29/00;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C07K14/705;G01N33/68 |
主分类号 |
G01N33/50 |
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