| 摘要 |
FIELD: organic chemistry, cosmetics, pharmacy. SUBSTANCE: invention describes biaromatic compounds of the general formula (I) where R1 means hydrogen atom or radical -(CH2)n-OR7, R2 means radical -(CH2)n-OR8, -X-Y means a bond taken among linkages that can be bound both from the left to the right and from to the right to the left; R3 means chain comprising 4-8 carbon atoms substituted with one or some hydroxyl groups being hydroxyl groups can be protected as methoxy-group and, possibly and except for, they can be substituted with one or some groups of lower alkyl and/or where one or some carbon atoms in chain can be replaced with one or some oxygen or nitrogen atoms. If necessary, nitrogen atoms can be substituted with radicals of lower alkyl and/or where one or some single bonds in chain are replaced with one or some double bonds or with double and triple bond; R3 is in benzene cycle at para- or meta-position to the bond X-Y; R4, R5, R6, are similar or different and mean hydrogen atom, lower alkyl, radical -OR10, n = 0 or 1; R7 and R8 mean hydrogen atom; R9 means hydrogen atom or lower alkyl; W means oxygen, sulfur atom, radical -CH2- or radical NH substituted with lower alkyl; R10 - means lower alkyl, and optical or geometrical isomers of indicated compounds. Invention describes also pharmaceutical composition eliciting agonistic activity with respect to receptors of vitamin D and cosmetic composition used for care body or hair based on indicated compounds. Invention provides the development of novel compounds that elicit selective activity with respect to proliferation and differentiation of cells. EFFECT: valuable properties of composition. 9 cl, 4 dwg, 2 tbl
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