| 摘要 |
PURPOSE: Provided are arene(alkane)sulfonylpyridazinone derivatives represented by the formula(I) which are used as activators of carboxyl acid and sulfonylation reagents for alcohol or amine, making them utilizable in various synthetic reactions. The pyridazinone reagents are recoverable, easily handled, stable and very reactive. CONSTITUTION: A preparation method of pyridazinone derivatives of the formula (I) comprises reacting pyridazinone derivatives of the formula(II) with corresponding sulfonyl halides. In the formula (I) and (II) X, Y, Z are independently same or different substituted halogen atom, alkoxy, phenoxy, azido groups; R is independently alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, and substituted heterocyclealkyl.
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