The invention is directed to entrapped binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrices, and their use as analyte biosensors both in-vitro and in vivo. The binding proteins are covalently bound to a fluorescein dye so that the concentration of an analyte (e.g., glucose) in a given sample is proportional to the fluorescence signal on a scale.
申请公布号
WO03057734(A1)
申请公布日期
2003.07.17
申请号
WO2003US00201
申请日期
2003.01.06
申请人
BECTON, DICKINSON AND COMPANY;ALARCON, JAVIER;KNORS, CHRISTOPHER, J.;PITNER, J., BRUCE
发明人
ALARCON, JAVIER;KNORS, CHRISTOPHER, J.;PITNER, J., BRUCE