发明名称 |
Conjugate heat shock protein-binding peptides |
摘要 |
The present invention relates (i) to conjugate peptides engineered to noncovalently bind to heat shock proteins; (ii) to compositions comprising such conjugate peptides, optionally bound to heat shock protein; and (iii) to methods of using such compositions to induce an immune response tin a subject in need of such treatment. It is based, at least in part, on the discovery of tethering molecules which may be used to non-covalently link antigenic peptides to heat shock proteins. The present invention also provides for methods of identifying additional tethers which may be comprised, togethter with antigenic sequences, in conjugate peptides.
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申请公布号 |
US2003134787(A1) |
申请公布日期 |
2003.07.17 |
申请号 |
US20020052578 |
申请日期 |
2002.01.17 |
申请人 |
ROTHMAN JAMES E.;MAYHEW MARK;HOE MEE H.;HOUGHTON ALAN;HARTL ULRICH;OUERFELLI OUATHEK;MOROI YOICHI |
发明人 |
ROTHMAN JAMES E.;MAYHEW MARK;HOE MEE H.;HOUGHTON ALAN;HARTL ULRICH;OUERFELLI OUATHEK;MOROI YOICHI |
分类号 |
C12N15/09;A61K35/00;A61K35/02;A61K39/385;A61K39/39;A61K47/42;A61K47/48;A61P3/10;A61P29/00;A61P31/04;A61P31/10;A61P31/16;A61P31/18;A61P31/22;A61P33/04;A61P33/06;A61P37/02;A61P37/04;C07K14/435;C07K14/47;C07K14/705;C07K19/00;C12N15/00;(IPC1-7):A61K38/17;C12Q1/70;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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