发明名称 |
Assay for screening candidate drug for the treatment of inflammatory diseases and methods for treating the same |
摘要 |
The invention relates to an assay to select a candidate drug for the treatment of inflammatory disease due to cytokine production. The assay comprises: a) exposing said candidate drug to intestinal cells; and b) analysing the effect of the said candidate drug selected from the group consisting of the variation of nuclear export or import of transcription factors from the NF-kappaB family the disruption of transcriptional activity of transcription factors from the NF-kappaB family, the differential histone acetylation of p65 (RelA); the variation of the amount of PPARgamma/RelA complexes in the cytosol of the cells; and a combination thereof. The invention further relates to methods for the treatment of inflammatory cytokine production associated diseases and to the use of a therapeutically effective dose of Bacteroides thetaiotaomicron or a component thereof.
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申请公布号 |
US2003133875(A1) |
申请公布日期 |
2003.07.17 |
申请号 |
US20020285224 |
申请日期 |
2002.10.31 |
申请人 |
ROWETT RESEARCH INSTITUTE |
发明人 |
KELLY DENISE |
分类号 |
G01N33/50;A61K31/02;A61K35/74;A61K45/00;A61P1/00;A61P1/04;A61P7/00;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P37/00;A61P37/04;C12N1/20;C12Q1/02;G01N33/15;G01N33/68;(IPC1-7):A61K49/00;G01N33/53;G01N33/567;G01N33/554;G01N33/569 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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