ANTI-RETROVIRAL 5,6-DISUBSTITUTED ACYCLOPYRIMIDINE NUCLEOSIDE DERIVATIVES

摘要

The present invention provides novel pyrimidine nucleoside derivatives represented by the following formula (I): HN I R2 CH (CH2)n 2,X 1 SIMILAR D3 wherein R<1> represents e.g. an alkyl group; RZ represents e.g. a phenyl group or a 3,5-dimethylphenyl group; and R<3> represents e.g. a vinyl group or a ethynyl group; A, B and X represent e.g. oxygene atoms; Z represents e.g. a methylene group or a carbonyl group; n is e.g. 1. The compounds were found to be highly active against wild-type and mutant HIV-1.