INSULIN-RESPONSIVE DNA BINDING PROTEIN-1 AND METHODS TO REGULATE INSULIN-RESPONSIVE GENES

摘要

The present invention relates to the novel protein Insulin−Responsive DNA Binding Protein−1 (IRDBP−1) and nucleotide sequences that encode it. IRDBP−1 binds to nucleic acid regions of genes that respond when cells are exposed to insulin. IRDBP−1 regulates genes important in mediating the insulin response in mamals and in regulating conditions such as diabetes, obesity, insulin−resistant syndrome and cell proliferative disorders. The present invention provides nucleic acids useful as probes for detecting nucleic acids encoding regions of the IRDBP−1 protein. Within the scope of the present invention are recombinant cells, tissues and animals containing non−naturally occurring recombinant nucleic acid molecules encoding IRDBP−1, including expression vectors, antibodies specific for IRDBP−1, assays for IRDBP−1 polypeptide, and methods relating to all of the foregoing, the development of therapeutic and diagnostic agents that mimic, facilitate or inhibit the actionof IRDBP−1, and/or are based on relationships ot the structure and action of IRDBP−1.