摘要 |
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met and its agonist ligand HGF. Disclosed herein are (a) mAbs and hybridoma cell lines that produce them, which mAbs antibodies are specific for Met and (b) combinations of anti-Met and anti-HGF mAbs. When detectably labeled, these antibodies are useful for imaging such tumors. Anti-Met mAb compositions and methods for scintigraphic detection, diagnosis, prognosis, monitoring and therapy of Met-bearing tumors are provided. |
申请人 |
VAN ANDEL INSTITUTE;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;HAY, RICK, V.;CAO, BOLIANG;RESAU, JAMES, H.;VANDE WOUDE, GEORGE, F.;GROSS, MILTON, D. |
发明人 |
HAY, RICK, V.;CAO, BOLIANG;RESAU, JAMES, H.;VANDE WOUDE, GEORGE, F.;GROSS, MILTON, D. |