Process for the preparation of a deoxyuridine derivative

摘要

A process for the preparation of 5'-deoxy-5-fluorouridine, which comprises the transformation of 2',3'-O-isopropylidene-5-fluorouridine in the corresponding 5'-O-sulfonyl derivative, subsequent reaction with alkaline or earth-alkaline iodides and, after hydrolysis of the isopropylidene group, reduction of the 5'-deoxy-5'-iodo-5-fluorouridine thus obtained, is described.