| 摘要 |
In accordance with the present invention, there is provided a class of pyridine compounds of formula (I) which are modulators of acetylcholine receptors. The compounds of the in- vention displace acetylcholine receptor ligands from their binding sites. In- vention compounds may act as ago- nists partial agonists, antagonists or allosteric modulators of acetylcholine receptors and are useful for a variety of therapeutic applications, such as the treatment of Alzheimer's disease and other disorders involving memory loss and or dementia (including AIDS dementia): disorders of attention and focus (such as attention deficit disorder); disorders of extrapyramidal motor function such as Parkinson's disease, Hu nting- ton's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, panic, anxiet y and psychosis; substance abuse including withdrawal syndromes and substitution therapy; neuroendocrine disorders and dysregulation o f food intake, including bulimia and anorexia; disorders of nociception and control of pain: autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid se- cretion and ulcers; pheochromocytoma; cardiovascular dysfunction including hypertension and cardia arrhythmias, comedication in surg ical procedures, and the like.
|
