The invention relates to novel alkansulfonamides of structure (I), wherein R<sp>1</sp> is a lowel alzyl group and the other variables are as defined in the description, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention aslo concerns related aspects inluding processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists in the treatment and prevention of diseases associated to the endothelin system.
申请公布号
WO03055863(A1)
申请公布日期
2003.07.10
申请号
WO2002EP13970
申请日期
2002.12.10
申请人
ACTELION PHARMACEUTICALS LTD;BOLLI, MARTIN;BOSS, CHRISTOPH;CLOZEL, MARTINE;FISCHLI, WALTER;WELLER, THOMAS
发明人
BOLLI, MARTIN;BOSS, CHRISTOPH;CLOZEL, MARTINE;FISCHLI, WALTER;WELLER, THOMAS