| 摘要 |
<p>Novel tumour selective antineoplastic agents are characterized, in that to customary antineoplastic agents are attached one or two very specific unbranched &Omega;-hydroxyalkyl, (&Omega;-hydroxy)alkenyl, &Omega;-(2,3-dihydroxypropyloxy)alkyl or an (&Omega;-(2,3-dihydroxypropyloxy))alkenyl groups R?2 and R3¿ with 5 to 30 carbon atoms, forming a tumour selective conjugate as exemplified with the compounds of formulae I, II and III []wherein R1 is a customary pharmaceutically acceptable inorganic or organic leaving group and A is 1,2-dimethylene, 1,3-trim ethylene, 1,2-cyclopentylene or 1,2-cyclohexylene. These compounds as well as their pharmaceutically acceptable salts, ester and prodrug derivatives are valuable chemotherapeutics</p> |
