| 发明名称 |
A SYSTEM FOR STABLE EXPRESSION OF SIRNAS IN MAMMALIAN CELLS |
| 摘要 |
The present invention provides a polynucleotide comprising a RNA polymerase III promoter, a region encoding a siRNA, and a transcriptional termination element comprising five consecutive thymine residues. The invention also provides for vectors, cells and non-human transgenic animal comprising the polynucleotides of the invention as well as their use in medicaments for various conditions.
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| 申请公布号 |
CA2470903(A1) |
申请公布日期 |
2003.07.10 |
| 申请号 |
CA20022470903 |
申请日期 |
2002.12.19 |
| 申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
BRUMMELKAMP, THIJN;AGAMI, REUVEN |
| 分类号 |
A01K67/027;A61K31/7088;A61K31/711;A61K35/12;A61K35/76;A61K38/00;A61K45/00;A61K48/00;A61K49/00;A61P1/18;A61P29/00;A61P31/14;A61P31/18;A61P35/00;A61P35/02;A61P35/04;A61P37/08;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/11;C12N15/113;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;(IPC1-7):C12N15/11;A61K31/713 |
主分类号 |
A01K67/027 |
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