INTERMEDIATES FOR LHRH ANTAGONIST SYNTHESIS, PROCESS FOR THEIR PRODUCTION, AND PROCESS FOR LHRH ANTAGONIST PRODUCTION

摘要

The novel tripeptides Ac-D-2Nal-D-4ClPh-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the heptapeptides P<1>-Ser(P<2>)-NMeTyr(P<3>)-D-Lys(Nic)-Leu-Lys(iPr,P<4>)-Pro-D-AlaNH2 and P<1>-Ser(P<2>)-NMeTyr(P<3>)-D-Asn-Leu-Lys(iPr,P<4>)-Pro-D-AlaNH2.