BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-alpha CONVERTING ENZYME (TACE)

摘要

The present application describes novel bicyclic lactam derivatives of formula (I) or pharmaceutically acceptable salt forms th ereof, wherein A, B, C, D, R1, and R2 are defined in the present specification, which are useful as metalloprotease, TNF-alpha, and/or aggrecanase inhibitors.