| 摘要 |
A compound of formula (I) wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to three additional nitrogen atoms and optionally substituted by one or more groups "R" selected from halogen, -NraRb, C1-6alkyl, C2-6alkenyl, C3-6alkenyl, aryl, heteroaryl, hydroxy, -OC1-6alkyl, formyl, cyanao, trifluoromethyl, -CHNORa, -CO2Ra, CONRaRb,-NraC(O)Ra, -NraC(O)Ora, -OC(O)NraRb, -OC(O)Ra, -OC(O)ORa, or a C1-6alkyl group substituted by one or more groups selected from hydroxy, NraRb, -OC1-6alkyl, SRa, CHNORa, CO2Ra, CONRaRb, NraC(O)Ra, -NRaC(O)Ora, -OC(O)NraRb, -OC(O)Ra, -OC(O)ORa. X represents -NrxRy or -OC1-6alkyl optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, amino and trifluoromethyl. Ra and Rb independently represents hydrogen or C1-6alkyl (preferably methyl); R1 represents hydrogen, C1-6alkyl or together R1 and R3 represents a CH2 moiety; R2 represents hydrogen, -OC1-6 alkyl, -O(O)C1-6alkyl or hydroxy; R3 represents hydrogen, hydroxy or together R3 and R1 represent a CH2 moiety; R4 represents hydrogen or C1-6 alkyl, optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, amino and trifluoromethy; Rx and Ry independently represents hydrogen, benzyl, C3-6cylcoalkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkyl optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, NraRb and trifluoromethyl, -C1-6alkylcycloalkyl, -C1-6alkylheterocycle, C1-6alkylamino and C1-6alkythio or together Rx and Ry form a heterocycle; and pharmaceutically acceptable derivatives and solvates thereof. |
