发明名称 |
HEPTAPEPTID OXYTOCIN ANALOGEN |
摘要 |
PCT No. PCT/SE97/01968 Sec. 371 Date Aug. 2, 1999 Sec. 102(e) Date Aug. 2, 1999 PCT Filed Nov. 21, 1997 PCT Pub. No. WO98/23636 PCT Pub. Date Jun. 4, 1998Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal beta -aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the beta -aminoalcohol Z is -NR-CH(Q)-CH2OH, Q is (CH2)n-NH-A is H or -C(=NH)NH2, and R is CH3 or C2H5, and the moiety S wherein H is a D-aromatic alpha -aminoacid and Y is an aliphatic alpha -aminoacid and have oxytocin antagonist activity. Also disclosed is: a method of their synthesis; pharmaceutical compositions containing these analogues; the synthesis of such compositions; a method of control of uterine contractions. |
申请公布号 |
DE69722651(D1) |
申请公布日期 |
2003.07.10 |
申请号 |
DE1997622651 |
申请日期 |
1997.11.21 |
申请人 |
FERRING B.V., HOOFDORP |
发明人 |
MELIN, PER;NILSSON, ANDERS;TROJNAR, JERZY;AURELL, CARL-JOHAN;RIVIERE, PIERRE;HAIGH, ROBERT |
分类号 |
A61K38/00;A61K38/11;A61P5/10;A61P15/00;A61P15/04;A61P15/06;A61P15/10;A61P15/14;A61P25/00;A61P25/18;A61P25/28;A61P29/00;A61P35/00;A61P37/02;C07K7/02;C07K7/16;(IPC1-7):C07K7/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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