SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINIUM SALTS, METHOD FOR PRODUCTION AND USE THEREOF AS A MEDICAMENT AND MEDICAMENTS COMPRISING THESAME

摘要

Compounds of formula (I), where R1 to R10 have the meanings given in the claims are particularly suitable as anti-hypertensives, for the reduction or prevention of ischaemic induced injury, as medicament for operative intervention in the treatment of ischaemia of the nervous system, stroke, cerebral oedema, shock, disrupted respiration, treatment of snoring, as laxative, as agent against ectoparasites, for prevention of gallstone formation, as antiatherosclerotic, as agent against late diabetic complications, carcinogenic disease states, fibrotic diseases, endothelial dysfunctions, organ hypertrophias and hyperplasias. Said compounds are inhibitors of cellular sodium/proton antiporters, influence serum lipoproteins, and can be used for prophylaxis and regression of atherosclerotic changes.