发明名称 |
IL-17 RECEPTOR-LIKE PROTEIN, USES THEREOF, AND MODULATION OF CATABOLIC ACTIVITY OF IL-17 CYTOKINES ON BONE AND CARTILAGE |
摘要 |
This invention relates, first, to the discovery of IL-17RL, a receptor for members of the IL-17 cytokine family, particularly IL-17B. IL-17RL is naturally expressed from a 19-exon gene as a 720 amino acid protein and as any of 11 splice variants created from differential splicing of the 19 exons. The invention further relates to the discovery that IL-17B is involved in catabolic degradation of bone and cartilage and that bone and cartilage disorders can be ameliorated by pharmacological manipulation of IL-17B by antibodies or by using IL-17RL as a decoy to reduce IL-17B related catabolic activity. Methods for diagnosing cartilage disorders, and pharmaceutical compositions for slowing or ameliorating bone and cartilage pathologies are also provided. |
申请公布号 |
WO0238764(A3) |
申请公布日期 |
2003.07.10 |
申请号 |
WO2001US43855 |
申请日期 |
2001.11.13 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;HAUDENSCHILD, DOMINIK;ROSE, LARRY;MOSELEY, TIMOTHY;REDDI, A., HARI |
发明人 |
HAUDENSCHILD, DOMINIK;ROSE, LARRY;MOSELEY, TIMOTHY;REDDI, A., HARI |
分类号 |
A61K38/00;A61P19/08;C07K14/54;C07K14/715;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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