发明名称 |
Inhibitors and disassemblers of fibrillogenesis |
摘要 |
Methods and compositions are presented that inhibit fibril formation and/or bring about disassembly of pre-formed fibrils. Compositions include peptides with short beta-strands with two faces: one that can bind to beta-amyloids through hydrogen bonds, and one which blocks propagation of hydrogen bonding needed to form fibrils. Thus, short congeners of the fibril protein containing N-methyl amino acids or esters are provided for the inhibition of fibril formation and for the disassembly of pre-existing or pre-formed fibrils. Specific aspects address beta-amyloid fibrils; prion mediated fibrils; Huntington protein fibrils. Methods for screening for potential fibril inhibitors and disassemblers, diagnostic analysis and treatments are provided.
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申请公布号 |
US2003130484(A1) |
申请公布日期 |
2003.07.10 |
申请号 |
US20020103658 |
申请日期 |
2002.03.20 |
申请人 |
GORDON DAVID J.;MEREDITH STEPHEN C. |
发明人 |
GORDON DAVID J.;MEREDITH STEPHEN C. |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):A61K38/17;C07K14/435;G01N33/53 |
主分类号 |
A61K38/00 |
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