发明名称 |
Morphine sulfate microgranules, manufacturing process and pharmaceutical preparations |
摘要 |
The present invention relates to a novel oral immediate-release morphine sulfate formulation in the form of microgranules. Each microgranule comprises a neutral support grain coated with a mixture of morphine sulfate and of a binder, such as hydroxypropylmethylcellulose, which represents 10 to 50% by weight of the morphine sulfate/binder mixture. The present invention also relates to a process for the preparation of these microgranules which is carried out entirely in aqueous medium on neutral support grains. The present invention finally relates to the pharmaceutical preparations comprising the microgranules according to the invention.
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申请公布号 |
US2003129244(A1) |
申请公布日期 |
2003.07.10 |
申请号 |
US20020259854 |
申请日期 |
2002.09.30 |
申请人 |
LABORATOIRES DES PRODUITS ETHIQUES ETHYPHARM |
发明人 |
DEBREGEAS PATRICE;LEDUC GERARD;OURY PASCAL;SUPLIE PASCAL |
分类号 |
A61K9/16;A61K9/50;A61K31/485;A61K47/38;A61P25/04;(IPC1-7):A61K31/485;A61K9/14 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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