发明名称 |
TRANSGENIC ORGANISM |
摘要 |
A method of producing a transgenic cell comprising into a cell a non-primate lentiviral expression vector comprising a nucleotide of interest (NOI). Also described is a method of producing a transgenic cell comprising introducing into a cell a lentiviral expression vector comprising a NOI capable of generating an antisense oligonucleotide, a ribozyme, an siRNA, a short hairpin RNA, a micro-RNA, a micro-RNA or a group 1 intron. Also described is a viral vector comprising a first nucleotide sequence, wherein said first nucleotide sequence comprises: (a) a second nucleotide sequence comprising an aptazyme; and (b) a third nucleotide sequence capable of generating a polynucleotide; wherein (a) and (b) are operably linked and wherein the aptazyme is activatable to cleave a transcript of the first nucleotide sequence such that said polynucleotide is generated. |
申请公布号 |
WO03056022(A2) |
申请公布日期 |
2003.07.10 |
申请号 |
WO2002GB05901 |
申请日期 |
2002.12.23 |
申请人 |
OXFORD BIOMEDICA (UK) LIMITED;RADCLIFFE, PHILIPPA;MITROPHANOUS, KYRIACOS;THEMIS, MICHAEL |
发明人 |
RADCLIFFE, PHILIPPA;MITROPHANOUS, KYRIACOS;THEMIS, MICHAEL |
分类号 |
A01K67/027;A61K48/00;C12N5/10;C12N15/09;C12N15/85;C12N15/867 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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