发明名称 |
Stable granulates containing S-Adenosylmethionine and process for the preparation thereof |
摘要 |
A fluid bed granulation process for manufacturing non-hygroscopic, stable granulates containing a water-soluble salt of S-adenosylmethionine is described. Said process comprises: a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) and b) the fluid bed granulation of the mixture. Granulates obtainable by said process and solid oral pharmaceutical forms obtainable by said granulates are disclosed.
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申请公布号 |
EP1325740(A1) |
申请公布日期 |
2003.07.09 |
申请号 |
EP20010204863 |
申请日期 |
2001.12.12 |
申请人 |
CHEMISTRY & HEALTH INTERNATIONAL B.V. |
发明人 |
CANTABENE, CARLO;MAGRI', PAOLO |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K9/50;A61K31/7076;(IPC1-7):A61K9/16;A61K31/707 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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