The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can inclu de a continuous stretch of at least 90 codons all of which are common codons.</ SDOAB>
申请公布号
EP1325138(A2)
申请公布日期
2003.07.09
申请号
EP20010984006
申请日期
2001.10.11
申请人
TRANSKARYOTIC THERAPIES, INC.
发明人
SELDON, RICHARD F.;MILLER, ALLAN M.;TRECO, DOUGLAS S.
