| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new VEGF antisense compound effective for suppressing the action of VEGF and useful for the treatment of diseases in which the vascularization or vascular permeation promotion by VEGF is participated. <P>SOLUTION: The compound is expressed by general formula H0-B1-B2-B3-B4- B5-B6-B7-B8-B9-B10-B11-B12-B13-B14-B15-B16-B17-B18-B19-B20-B21-B22-H (I) (B1 to B3, B8, B11 and B20 are each independently C<SP>p</SP>or the like; B4, B5, B7, B9, B12, B14 to B16 and B21 are each independently A<SP>p</SP>or the like; B6, B10, B13 and B17 are each independently G<SP>p</SP>or the like; B18 and B19 are each independently T<SP>p</SP>or the like; and B22 is T<SP>t</SP>or the like) and its pharmacologically permissible salt. <P>COPYRIGHT: (C)2003,JPO |
