发明名称 |
Phthalazine derivatives as phosphodiesterase 4 inhibitors |
摘要 |
Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C1-4)alkyl optionally substituted; R1 is (C1-6)alkyl or polyfluoro(C1-6)-alkyl; R2 is (C4-7)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N->O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNFalpha inhibitors.
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申请公布号 |
US6589951(B1) |
申请公布日期 |
2003.07.08 |
申请号 |
US20000581506 |
申请日期 |
2000.08.10 |
申请人 |
ZAMBON GROUP S.P.A. |
发明人 |
NAPOLETANO MAURO;NORCINI GABRIELE;BOTTA DANIELA;GRANCINI GIANCARLO;MORAZZONI GABRIELE;SANTANGELO FRANCESCO;SIRO HERRERO JORGE G.;GARCIA NAVAIO JOSE LUIS;ALVAREZ-BUILLA JULIO G. |
分类号 |
A61K31/502;A61P11/00;A61P11/06;A61P27/16;A61P29/00;A61P37/08;A61P43/00;C07D237/30;C07D237/34;C07D401/06;C07D401/12;C07D405/12;C07D405/14;(IPC1-7):A61K31/502 |
主分类号 |
A61K31/502 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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