发明名称 |
Pediatric formulation of gatifloxacin |
摘要 |
There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid and palmitic acid in a narrow weight ratio has been found to effectively mask the bitter taste of gatifloxacin. The taste of gatifloxacin is effectively masked in the mouth and in aqueous suspension through a full dosage cycle, typically fourteen days. Gatifloxacin in the subject crystalline co-precipitates has been found to be readily available for absorption from the stomach.
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申请公布号 |
US6589955(B2) |
申请公布日期 |
2003.07.08 |
申请号 |
US20020143487 |
申请日期 |
2002.05.09 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
RAGHAVAN KRISHNASWAMY S.;RANADIVE SUNANDA A.;BEMBENEK KENNETH S.;BENKERROUR LOUTFY;TROGNON VERONIQUE;CORRAO RICHARD G.;ESPOSITO LUIGI |
分类号 |
C07D401/04;A61K31/445;A61K31/496;A61K47/12;A61P31/04;C07D215/56;C07D401/10;(IPC1-7):A61K31/496;C07D40/10 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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