发明名称 |
Method for enhancing mutant enzyme activities in lysosomal storage disorders |
摘要 |
Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. |
申请公布号 |
US6589964(B2) |
申请公布日期 |
2003.07.08 |
申请号 |
US20020172604 |
申请日期 |
2002.06.14 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY |
发明人 |
FAN JIAN-QIANG;ISHII SATOSHI |
分类号 |
A61K31/445;A61K31/4465;A61K31/7008;A61K31/7042;A61K31/7052;A61K31/706;A61P43/00;C07D207/12;C07D211/46;C07H17/02;C12N9/40;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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