发明名称 |
POLYAZAMACROCYCLIC COMPOUNDS FOR COMPLEXATION OF METAL IONS |
摘要 |
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses. The compound has for- mula (I), where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y; y is 3 or4; R is (CH2)Z P(=0)(R1)(OR2); R1 is R3 or OR3 where R3 is alkyl, cycloalkyl or aryl; R2 is H, alkyl or a where R4 is alkyl, cycloalkyl or aryl; and z is 1 to 3. In one important embodiment, this compound may be complexed with a metal to be a polyazamacrocyclic compound-metal com- plex having formula (II), where r is 2 or 3; and Me is a metal ion. Such complexes are useful for enhancing a magnetic res- onance image of a subject.
|
申请公布号 |
CA2095615(C) |
申请公布日期 |
2003.07.08 |
申请号 |
CA19912095615 |
申请日期 |
1991.11.12 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SHERRY, A. DEAN;LAZAR, ISTVAN;RAMASAMY, RAVICHANDRAN;BRUCHER, ERNO |
分类号 |
A61B5/055;A61K49/00;A61K49/06;A61K51/04;C07D255/02;C07D257/02;C07F9/40;C07F9/6515;C07F9/6524;G01R33/28;(IPC1-7):C07F9/547 |
主分类号 |
A61B5/055 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|