| 摘要 |
PURPOSE: A method for preparing a diphenyl ether derivative substituted with halogen is provided, to reduce the cost and the preparation time by employing a sodium salt of halogen acid and an acid solution instead of chlorine gas, to reduce the amount of by-product and to improve the yield. CONSTITUTION: The method comprises the steps of reacting diphenyl ether represented by the formula 2 with sodium salt of halogen acid in the presence of an acid solution to prepare 2,4,4'-trihalogen diphenyl ether represented by the formula 3; reacting the obtained compound of the formula 3 with acetyl chloride in the presence of an aluminium catalyst to prepare 2,4,4'-trihalogen-2'-acetyldiphenyl ether represented by the formula 4; reacting the obtained compound of the formula 4 with maleic anhydride in the presence of hydrogen peroxide to prepare 2,4,4'-trihalogen-2'-acetoxydiphenyl ether represented by the formula 5; and reacting the obtained compound of the formula 5 with a strong base to prepare 2,4,4'-trihalogen-2'-hydroxydiphenyl ether represented by the formula 1, wherein X is Cl or Br.
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