| 摘要 |
PURPOSE: A novel catechol benzamide derivative, its preparation method and a pharmaceutical composition containing the derivative are provided, which derivative inhibits the phosphodiesterase IV or the tumor necrosis factor (TNF). CONSTITUTION: The catechol benzamide derivative is represented by the formula 1, wherein R1 is a cycloalkyl group of C3-C7, an indanyl group or a benzyl group; and X and Y are independently H, an alkyl group of C1-C7, an alkoxy group of C1-C7, a nitro group, an amino group or a halogen atom, or X is -NH-Z-R2 and Y is H (wherein R2 is an alkyl group of C1-C7 substituted or unsubstituted with one or two group selected from the group consisting of a halogen atom, OH, an acetoxy group, an alkoxy group of C1-C3 and an amino group, or a phenyl group substituted or unsubstituted with one or two group selected from the group consisting of a nitro group, a cyano group, a halogen atom, an alkyl group of C1-C3 and an alkoxy group of C1-C3, and the halogen atom is F, Cl or Br).
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