摘要 |
PROBLEM TO BE SOLVED: To obtain a neurogenic ache suppressant excellent in analgesic action on the neurogenic ache. SOLUTION: This suppressant contains, as the effective component, a 4- hydroxy-4-phenylpiperidine derivative represented by formula (1) [wherein R<SP>1</SP>and R<SP>2</SP>are each H, a lower alkyl, or the like; and R<SP>3</SP>is H or (CR<SP>4</SP>R<SP>5</SP>)<SB>n</SB>-Y (wherein R<SP>4</SP>and R<SP>5</SP>are each H or a lower alkyl; Y is COOR<SP>6</SP>, CONR<SP>7</SP>R<SP>8</SP>, OR<SP>9</SP>, or OCOR<SP>10</SP>; R<SP>6</SP>, R<SP>9</SP>, and R<SP>10</SP>are each H, a lower alkyl, or the like; and R<SP>7</SP>and R<SP>8</SP>are each H, a lower alkyl, or the like; and (n) is 1-6)] or its salt. COPYRIGHT: (C)2003,JPO
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