发明名称 |
TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS |
摘要 |
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and / or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and / or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
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申请公布号 |
WO03053977(A1) |
申请公布日期 |
2003.07.03 |
申请号 |
WO2002US38486 |
申请日期 |
2002.12.02 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
KANOJIA, RAMESH, M.;JAIN, NARESHKUMAR, F.;NG, RAYMOND;SUI, ZHIHUA;XU, JIAYI |
分类号 |
C07D311/58;A61K31/37;A61K31/4025;A61K31/4523;A61K31/453;A61K31/5377;A61K31/55;A61K45/00;A61P3/06;A61P9/00;A61P13/08;A61P15/00;A61P15/18;A61P19/02;A61P19/10;A61P25/00;A61P25/28;A61P35/00;A61P43/00;C07D311/64;C07D313/18;C07D493/04;C07F7/08;C07F7/18;(IPC1-7):C07D493/04;A61K31/35 |
主分类号 |
C07D311/58 |
代理机构 |
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代理人 |
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