发明名称 |
HUMAN ANTIBODIES AGAINST HUMAN GLYCOPROTEIN VI AND THEIR USE |
摘要 |
Specific binding members directed to human glycoprotein VI (GPVI), in particular human antibodies, may employ the antibody VH and/or VL domain of the scFv fragment herein termed 10B12 or one or more complementarity determining regions (CDRs) of the 10B12 heavy chain variable (VH) and/or lig ht chain variable (VL) domains, especially VH CDR3 in other antibody framework regions. Antibody molecules are provided with advantageous and unexpected properties, especially ability to inhibit collagen-induced platelet aggregation and the adhesion of platelets to Collagen-Related Peptide (CRP). Domain 1 of human GPVI is a primary target for the 10B12 antibody with these properties, and the epitope includes lysine 59. |
申请公布号 |
CA2510745(A1) |
申请公布日期 |
2003.07.03 |
申请号 |
CA20022510745 |
申请日期 |
2002.12.18 |
申请人 |
CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTD |
发明人 |
OUWEHAND, WILLEM HENDRIK;SMETHURST, PETER ALEXANDER;FARNDALE, RICHARD WILLIAM |
分类号 |
A61P7/02;C07K16/28;C12N15/13;(IPC1-7):C07K16/28;C12N5/10;A61K39/395 |
主分类号 |
A61P7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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