发明名称 |
RECEPTOR TYROSINE KINASE WITH A DISCOIDIN-TYPE BINDING DOMAIN |
摘要 |
A breast carcinoma tyrosine phosphoprotein, DDR (Discoidin Domain Receptor), that defines a novel class of receptor tyrosine kinases is presented. The DDR cDNA predicts a polypeptide C-terminal tyrosine kinase domain and an N-terminal domain similar to the Dictyostelium discoideum lectin discoidin I. These domains are connected by an extraordinary hydrophilic proline/glycine-rich domain, which is interrupted by a predicted transmembrane sequence. This extended proline/glycine-rich region suggests an unusual geometry of interaction with ligand or substrates. Discoidin I-type domains may interact with specific cell surface molecules.
|
申请公布号 |
US2003124133(A1) |
申请公布日期 |
2003.07.03 |
申请号 |
US19980140378 |
申请日期 |
1998.08.26 |
申请人 |
JOHNSON JEFFREY D.;RUTTER WILLIAM J.;EDMAN JEFFREY C. |
发明人 |
JOHNSON JEFFREY D.;RUTTER WILLIAM J.;EDMAN JEFFREY C. |
分类号 |
A61K38/45;A61K39/00;C07K14/705;C12Q1/48;G01N33/574;G01N33/68;(IPC1-7):G01N33/53;C07H21/04;G01N33/567;C12P21/06;A61K39/38;C07K5/00;C07K7/00;C07K16/00;C07K17/00;A61K38/00 |
主分类号 |
A61K38/45 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|