METHODS AND DEVICES FOR PROTEOMICS DATA COMPLEXITY REDUCTION
摘要
Provided are methods and systems for identification of proteins using high mass accuracy mass spectrometry. Not only do high mass accuracy measurements provide greater confidence in protein identification assignments, but they also enable proteins to be identified with either less sequence coverage or fewer additional tandem MS experiments. In addition, high mass measurement accuracy optionally allows protein identifications to be made on the basis of the mass of a single peptide, providing higher-throughputs in the analysis of mixtures due to the significant decrease in time spent on additional tandem MS experiments. In addition, a concomitant time saving in the cross correlation process of mass spectral data with in silico digested databases would also be achieved.
申请公布号
WO03054772(A1)
申请公布日期
2003.07.03
申请号
WO2002US35607
申请日期
2002.11.05
申请人
IRM, LLC;BROCK, ANSGAR;HORN, DAVID, M.;PETERS, ERIC, C.