Isolated CDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA

摘要

Tumor Necrosis Factor (TNF) Binding Protein is isolated and substantially purified. It has the ability to inhibit the cytotoxic effect of TNF and/or to maintain its prolonged beneficial effects. Isolated cDNA encoding TNF Binding Protein II is obtained and may be used to produce expression vectors, prokaryotic or eukaryotic expression hosts and methods of obtaining the protein by culturing of such hosts.