Process for the catalytic asymmetric disubstitution of carboxamides using 2 different Grignard reagents

摘要

The invention relates to a method for asymmetrically disubstituting carboxylic acid amides on the geminal carbonyl-C atom using two different grignard reagents in the presence of a metal alcoholate compound used as a catalyst and in the presence of another organometallic compound used as a co-catalyst.