| 摘要 |
A soft, adherent, soluble oral patch for delivering topical medication in the mouth including a hydrophilic polymer that is liquid at human mouth temperatures. Preferably, the hydrophilic polymer gels to a solid at temperatures just below human mouth temperatures. The structure of the oral patch is formed with a porous network that remains solid at human mouth temperatures and slowly dissolves in saliva. In some embodiments, the network is elasto-plastic and in some cases it is hydrophilic. The hydrophilic polymer is located within pores of the network, along with a desired medication. The oral patch is formed by mixing and hydrating the ingredients, bringing them to a hot temperature just below boiling, and cooling them to form a gel. The hot mixture may be poured into molds and the mold may also serve as packaging for delivery. The packaging may comprise a germ barrier moisture passing film which allows the oral patch to dry out or become re-hydrated without growing mold.
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