DNA ENCODING NOVEL CYCLIC GMP DEPENDENT PROTEIN KINASES FROMTWO PROTOZOAL SOURCES FOR USE AS CHEMOTHERAPEUTIC TARGETS FOR ANTIPROTOZOALAGENTS

摘要

The present invention relates to novel protozoal cyclic GMP dependent protei n kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum. Nucleic acid molecules having sequences that enco de such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potenti al antiprotozoal agents. As well, methods to obtain such nucleic acid molecules , proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies an d inhibitors as well as their use to protect animals from disease caused by parasites such as Eimeria maxima and Plasmodium falciparum.