| 摘要 |
PROBLEM TO BE SOLVED: To provide a bicyclic nitrogen-containing heterocyclic compound having gonadotropin releasing hormone antagonism, and to provide a pharmaceutical composition containing the same. SOLUTION: This compound (a salt thereof) is shown by the formula [wherein, A and D are such that either one of them is N and the other C, or both of them being N atoms; B is N or C; R is a halogenobenzyl; R<SP>1</SP>is a (substituted) alkyl, (substituted) heterocyclic group, (substituted) amino or the like; R<SP>2</SP>is a (substituted) alkyl or the like; R<SP>3</SP>is a (substituted) alkyl or the like; and R<SP>4</SP>is a group of the formula (a) (wherein, R<SP>5</SP>is a halogen atom, alkyl, alkoxy or the like; and ring E is a benzene ring optionally having substituent(s) in addition to R<SP>5</SP>) or the like]. COPYRIGHT: (C)2003,JPO
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