The present invention relates to pressurized metered dose inhaler (pMDI) actuators (2) with laser drilled orifices and to medicinal aerosol solution formulation products comprising these actuators (2). In particular, the present invention relates to the optimisation of the output characteristics of drug solution formulations in hydrofluoroalkanes (HFAs) by use of pMDIs with actuators (2) with laser drilled orifices of specific dimensions. Moreover, the actuators (2) of the present invention allow the use of solution formulations with a high ethanol content and a high ratio of ethanol to active ingredients and thus, the use of poorly soluble active ingredients in solution formulations and allow the use of solution formulations which are substantially free of low volatility components.
申请公布号
WO03053501(A1)
申请公布日期
2003.07.03
申请号
WO2002EP14588
申请日期
2002.12.19
申请人
CHIESI FARMACEUTICI S.P.A.
发明人
DAVIES, REBECCA, JAYNE;GANDERTON, DAVID;LEWIS, DAVID, ANDREW;MEAKIN, BRIAN, JOHN