PROCESS FOR OBTAINMENT OF ENANTIOMERS_OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE; PROCESS FOR OBTAINMENT OF NON-RACEMIC MIXTURES BETWEEN THE ENANTIOMERS OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINOCARBOXAMIDE; COMPOUND CONSISTING OF NON-RACEMIC MIXTURES OF ENANTIOMERS OF N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2

摘要

The present invention describes a method of separation of the enantiomers of N−(2,6−dimethylphenyl)−1−propy l−2−piperidinocarboxamide.Another object of the present invention refers to the enantiomeric manipulation of the enantiomers of N−(2,6−dimethylphenyl)−1−propy l−2−piperidinocarboxamide, in order to achiever compounds and pharmaceutical compositions presenting diverse enantiomeric excesses of (S)− N−(2,6−dimethylphenyl)−1−propy l−2−piperidinocarboxamide, in order to quantify and determine the participation of (R)− N−(2,6−dimethylphenyl)−1−propy l−2−piperidinocarboxamide in the anesthetic and cardiotoxic effects. These compounds and compositions enantiomerically manipulated demonstrate to present a significant improvement in itsanesthetic properties, presenting a cardiotoxic profile equivalent to pure enantiomer, a (S)− N−(2,6−dimethylphenyl)−1−propy l−2−piperidinocarboxamide.