PANCREATIC LIPASE INHIBITOR COMPOUNDS, THEIR SYNTHESIS AND USE

摘要

The subject invention features compounds having the structure:, wherein X is O, S, CH2 or NR5; Y is O or S; R1 is H, substituted or unsubstituted C1­C15 alkyl, C1−C8 alkylaryl, −C(O)OR4, −C(O)NR4R5, −CR6R6'OR4,−CR6< /sb>R6'OC(O)R4, − CR6R6'OC(O)NHR7, −C(O)NR1oR11, −C(O)NR8R9 NR8R9, −N(R5)C(O)NHR5, or CH2R4; R2 is a substituted or unsubstituted, straight chain C1−C30 alkyl or branched C3 C30 alkyl, aryl, alkylaryl, arylalkyl, heteroarylalkyl or cycloalkyl; R3 is H or substituted or unsubstituted C1−C6 alkyl or C3−C10 cycloalkyl; R4 is H or a substituted or unsubstituted, straight chain or branched, C6−C30 alkyl, aryl, −CH2−aryl, aryl −C1−C15 alkyl, heteroaryl−C1−C15alkyl or C3−C10 cycloalkyl; R5 is H or a substituted or unsubstituted, straight chain or branched, C6−C30 alkyl, aryl C1−C30alkyl, heteroarylalkyl or cycloalkyl; R6 and R6' are each independently H, substituted or unsubstituted C1−C6 alkyl, dialkyl or C3−C10 cycloalkyl or together form a 3−7 membered ring system; R7 is H or substituted or unsubstituted C1−C12 alkyl or C3−C10 cycloalkyl; R8 and R9 are each independently H, substituted or unsubstituted C1−C6 alkyl, C1−C6 alkoxy, C1−C6 alkylaryl, or NR8R9 together form a substituted piperazine or piperidine ring or a dihydro−1H−isoquinoline ring system, or a specific enantiomer thereof, or a specific tautomer, or a pharmaceutically acceptable salt thereof and a method for treating diabetes or obesity by administering a therapeutically effective amount of the compounds of the invention.