Bioactive absorbable microparticles as therapeutic vaccines

摘要

A therapeutic vaccine for tumor immunotherapy is disclosed which comprises absorbable microparticles/nanoparticles capable of delivering immobilized stimulatory/costimulatory signals and releasing necessary cytokines to promote an anti-tumor effect. The microparticles/nanoparticles are formed of an absorbable crystalline polymer, preferably acid-terminated polyglycolide. Other bioactive agents such as tumor specific antigens, DNA or RNA may be immobilized of the surface of the particles.