| 发明名称 |
INSULIN MOLECULE HAVING PROTRACTED TIME ACTION |
| 摘要 |
The present invention provides an insulin molecule that provides a protracte d, even basal duration of action. The insulin molecule comprises a modification at the N-terminus of the A-chain, optionally a modification at the N-terminu s of the B-chain, a modification at a B-chain lysine, and optionally a modification at the C-terminus of the A-chain. The present invention also provides a method of treating diabetes mellitus comprising administering the insulin molecule.
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| 申请公布号 |
CA2468100(A1) |
申请公布日期 |
2003.07.03 |
| 申请号 |
CA20022468100 |
申请日期 |
2002.12.12 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
BEALS, JOHN MICHAEL;NG, KINGMAN;DEFELIPPIS, MICHAEL ROSARIO;MYERS, SHARON RUTH;MICANOVIC, RADMILA;KOHN, WAYNE DAVID;DIMARCHI, RICHARD DENNIS;ZHANG, LIANSHAN |
| 分类号 |
A61K38/28;A61P3/10;C07K14/62;(IPC1-7):C07K14/62;C07K1/06;C30B29/58 |
主分类号 |
A61K38/28 |
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