发明名称 |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PSORIASIS AND OTHER SKIN DISEASES |
摘要 |
The invention relates to a pharmaceutical composition for the treatment of psoriasis and other skin diseases. The inventive composition comprises 17- clobetasol propionate and a hydroxy derivative of progesterone having formul a (I) wherein: R6 denotes H or methyl; R11 denotes H or hydroxyl; and R17 denotes H or hydroxyl, but R11 and R17 cannot be H simultaneously. Preferabl y, said composition is administered as a lotion with: 0.05-0.2 % 17-clobetasol propionate; 0.3-1 % of (I); a solvent selected from among ethanol, isopropan ol and mixtures thereof; 40 % cosolvent selected from among propylene glycol, glycerine, sorbitol and mixtures thereof; and 20 % water. In the ideal lotio n, the solvent is ethanol and the cosolvents are approximately: 35 % propylene glycol, 5 % glycerine and 20 % water. The invention affords the following advantages: longer interval between recurrences and fewer local secondary effects. Moreover, the inventive composition can be used for the treatment o f psoriasis.
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申请公布号 |
CA2470364(A1) |
申请公布日期 |
2003.07.03 |
申请号 |
CA20022470364 |
申请日期 |
2002.12.11 |
申请人 |
LITAPHAR LABORATORIOS S.A. |
发明人 |
LARRANAGA LAZCANO, LIDIA;PIDAL FERNANDEZ, ROSALIA;TOMASI SCIANO, GIUSEPPE |
分类号 |
A61K8/63;A61K9/00;A61K31/57;A61K31/573;A61K47/10;A61K47/26;A61P17/00;A61P17/06;A61P29/00;A61P37/08;A61Q19/00;C07J7/00;(IPC1-7):C07J7/00 |
主分类号 |
A61K8/63 |
代理机构 |
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主权项 |
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